Opioids for breathlessness: a narrative review | BMJ Supportive ...
Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use of opioid medication. Opioids are being implemented variably in practice for chronic breathlessness. This narrative review summarises the evidence defining ...
Management of hiccups in palliative care patients
Treatment algorithm for persistent and intractable hiccups in palliative care patients. PPI, proton pump inhibitor. If intractable hiccups are caused by a central type of condition, baclofen (level II) is recommended as first-line treatment. It is the only drug that …
Breast cancer nursing interventions and clinical effectiveness: a ...
Methods Cochrane Controlled Register of Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline and Embase databases were searched (January 1999 to May 2019) to identify randomised controlled trials (RCTs) and controlled before-and-after studies of interventions delivered by nurses with oncology …
Anticipatory prescribing in community end-of-life care: systematic ...
Background The anticipatory prescribing of injectable medications is recommended practice in controlling distressing symptoms in the last days of life. A 2017 systematic review found practice and guidance was based on inadequate evidence. Since then, there has been considerable additional research, warranting a new review. Aim To review the evidence published since 2017 concerning anticipatory ...
Single-arm clinical trials: design, ethics, principles
Jun 4, 2024 · Clinical trial staging. Single-arm trials are a commonly used clinical trial design that can be applied in all four phases of clinical trials. In the phase I clinical trials, single-arm trials are employed to investigate the mechanism of action, pharmacokinetic properties and safety of a new drug, providing foundational data for subsequent clinical trials.15 The phase II …
Impact of dementia on informal care: a systematic review of family ...
Introduction Caregivers play a major role in providing all the support and care in daily activities for their relatives with dementia. To fully describe the influence of dementia caregiving on family caregivers’ life, we conducted a systematic review including caregivers’ perceptions about the positive and negative aspects of caring and the expressed factors. Materials and methods We ...
Hydration and symptoms in the last days of life
Introduction. Most patients with a deteriorating chronic illness have a reduced oral intake at the end of life. This may be due to illness or treatment-related symptoms or complications, such as dysphagia, nausea or vomiting, generalised weakness and, in the last days of life, to a decreased level of consciousness or a loss of desire to drink.1 2 …
Febrile neutropenia prophylaxis, G-CSF physician preferences: …
Jan 16, 2022 · Objectives Febrile neutropenia (FN) commonly occurs during cancer chemotherapy. Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is known to reduce the severity and incidence of FN and infections in patients with cancer. Despite the proven efficacy, G-CSFs are not always prescribed as recommended. We performed a discrete-choice experiment (DCE) to determine what factors drive ...
Supportive and Palliative Care Indicators Tool prognostic value in ...
May 31, 2021 · Background An increasing number of older patients are hospitalised. Prognostic uncertainty causes hospital doctors to be reluctant to make the switch from cure to care. The Supportive and Palliative Care Indicators Tool (SPICT) has not been validated for prognostication in an older hospitalised population. Aim To validate SPICT as a prognostic tool for risk of dying within one year in older ...
Homepage | BMJ Supportive & Palliative Care
BMJ Supportive & Palliative Care is a Plan S compliant Transformative Journal.. BMJ Supportive & Palliative Care holds an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, …