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For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...
Space, An Early Frontier. When a brain region is tau-negative by SUVR (green arrow, left), spatial extent (dark blue) correlates better with measures of disease severity than does SUVR (light blue).
Alzforum webpages for each DIAN-TU-eligible variant now state “DIAN-TU eligibility: Yes” near the top of the page and an explanation under the Pathogenicity section (see, for example, PSEN1 M146V ).
Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...
See α-Synuclein. Candidate tracer SY08 detects α-synuclein deposits in the brainstem (right) and parietal cortex (left) of ...
Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...
A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...
Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...