Background— We describe the first human experience with a permanently implantable, direct left atrial pressure (LAP) monitoring system in ambulatory patients with chronic heart failure. Methods and R ...

Background—Although frequently assessed in trials and clinical practice, hemodynamic response to therapy has never been validated as a surrogate end point for clinical events in pulmonary arterial hy ...

Background— The present study was performed to assess the association of prothrombotic risk factors and underlying conditions (infections, vascular trauma, immobilization, malignancies, autoimmune di ...

From the Department of Medicine (L.S.), Department of Emergency Medicine, Division of Emergency Medicine Research (E.P.H.), Division of Health Care and Policy ...

Background:Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins haptoglobin and hemopexin, which bind extracel ...

Originally published1 Feb 1982https://doi.org/10.1161/01.RES.50.2.175Circulation Research. 1982;50:175–191 ...

Background— Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction ≤35%, many such patients do not ...

Background— It is unclear whether atrial fibrillation (AF) drivers in humans are focal or reentrant. To test the hypothesis that functional reentry is involved in human AF maintenance, we determined ...

College of Nursing, University of Illinois at Chicago, Chicago, IL This analysis is part of a larger prospective, multicenter study examining the influence of sex on symptom characteristics during ACS ...

From the Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea (Y.-H.K.); Sansom Institute for Health Research, University of South Australia, Adelaide, Australia (J ...

Background—In this report, we provide the first normative reference data and prevalence estimates of impaired orthostatic blood pressure (BP) stabilization, initial orthostatic hypotension, and ortho ...

Background— Atherosclerotic plaque rupture, the most important cause of acute cardiovascular incidents, has been strongly associated with vascular inflammation. On the basis of the hypothesis that th ...