There are numerous player prop betting options on Isaac Guerendo for the 8:15 PM ET game Monday, which airs live on ABC/ESPN.

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 receiving yards in Monday's 40-34 loss to the Lions. Guerendo made a successful return from a one-game layoff due to ...

San Francisco 49ers rookie running back Isaac Guerendo had a useful fantasy day during a 40-34 loss to the Detroit Lions on ...

Taylor did not record a carry or a target while playing 13 offensive snaps (20 percent) in Monday's 40-34 loss to the Lions. Taylor reverted to the backup role in San Francisco after rookie Isaac ...

Isaac Guerendo, RB, SF (foot/hamstring) — Expected to play In Guerendo’s Week 16 absence, Patrick Taylor had eight carries for 24 yards, while WR Deebo Samuel had five carries for 25 yards. But ...

San Francisco 49ers host the Detroit Lions on Monday Night Football to disrupt the Lions' quest for the NFC's No. 1 seed.

The Detroit Lions will face the San Francisco 49ers in week 17 of the NFL season on Monday Night Football at Levi's Stadium on December 30th. WATCH ...

San Francisco 49ers head coach Kyle Shanahan recapped the team's 40-34 loss to the Detroit Lions, evaluated the 49ers performance on "Monday Night Football" and shared injury updates on QB Brock Purdy ...

The San Francisco 49ers suffered a 40-34 loss to the Detroit Lions on Monday night in a game that was much of the same for ...

Pearsall was drafted to solve the Niners’ man-to-man woes, and with him sidelined at the start of the season, every team with ...

The 49ers (6-9) have won so few they are vacating the NFC throne, having been eliminated last Sunday from playoff contention.

San Francisco 49ers TE George Kittle secured his 1,000-yard mark on the season with a 20-yard reception vs. the Lions.