According to Monday’s study, women with BRCA1 mutations should have preventive ovarian surgery– known as prophylactic oophorectomy – by age 35, as waiting appears to increase the risk of ...

BRCA1 belongs to a family of tumor suppressor genes, which make proteins that mend damaged DNA. Generally, a single functioning copy of a gene is sufficient to ensure normal function even when the ...

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer. Now, Shuklaet al.demonstrate that mice lacking BRCA1 in cardiomyocytes are more sensitive to ischaemia than control ...

For ovarian cancer, a BRCA1 mutation increases the risk from the 1.3% seen in the general population to 39%, and a BRCA2 mutation raises it to between 11% and 17%.

The tumour suppressor breast and ovarian cancer type 1 susceptibility protein (BRCA1) is integral for the maintenance of genome stability through its roles in cell cycle checkpoint control and DNA ...

The full name of the BRCA1 gene is “breast cancer 1, early onset” and it codes for a tumor suppressor protein. This article explores the gene function of the BRCA1 gene.

Learning I carried the BRCA1 mutation was terrifying, but it gave me the power to choose prevention, embrace survivorship, ...

BRCA1 variants, on the other hand, don't seem to be major contributors to disease initiation or progression, with only 1 somatic variant and 1 germline variant found in combination with a ...

A method for detecting a germline alteration in a BRCA1 gene, said alteration selected from the group consisting of the alterations set forth in Tables 11 and 12 which comprises analyzing a ...

BRCA1 or BRCA2 genes are more common in young women, and these mutations increase cancer risk by as much as 84%. Six percent of all breast cancer patients carry BRCA gene mutations, but in ...

Studies of the association between OCP use and BC risk for BRCA1 and BRCA2 mutation carriers have assessed ever use rather than current use, and the findings are conflicting. 7–18 Although most ...

It's a gene commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...