Women with BRCA1 mutations should remove their ovaries by age 35, according to a study that published online Monday.

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1 ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

The tumour suppressor breast and ovarian cancer type 1 susceptibility protein (BRCA1) is integral for the maintenance of genome stability through its roles in cell cycle checkpoint control and DNA ...

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer. Now, Shuklaet al.demonstrate that mice lacking BRCA1 in cardiomyocytes are more sensitive to ischaemia than control ...

Learning I carried the BRCA1 mutation was terrifying, but it gave me the power to choose prevention, embrace survivorship, ...

The research, published in Nature Communications, suggests this preemptive, two-part approach could be the most effective plan of treatment for early-stage breast cancer linked to BRCA1 and BRCA2 ...

A method for detecting a germline alteration in a BRCA1 gene, said alteration selected from the group consisting of the alterations set forth in Tables 11 and 12 which comprises analyzing a ...

The full name of the BRCA1 gene is “breast cancer 1, early onset” and it codes for a tumor suppressor protein. This article explores the gene function of the BRCA1 gene.

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression.

PURPOSEIt is uncertain whether, and to what extent, hormonal contraceptives increase breast cancer (BC) risk for germline BRCA1 or BRCA2 mutation carriers.METHODSUsing pooled observational data from ...

It's a gene commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...