Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating ...

Stomach cancer, also known as gastric cancer, is the fifth most common cancer worldwide, with nearly one million new cases in ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations.

It's time for researchers to reconsider the current paradigm of cancer as a genetic disease, argued Sui Huang from the ...

The study found that gastric cells in some individuals carried three copies of certain chromosomes, hinting toward exposure ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

Scientists have carefully examined somatic mutations in stomach lining tissue to uncover mutational mechanisms that can lead ...

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational ...

Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this ...