San Francisco 49ers running back Christian McCaffrey missed most of training camp and the entire preseason due to a calf strain and Achilles tendinitis, the latter of which kept him out of Week 1. On ...

Here's everything you need to know for Week 3 NFL games. Which teams will win? Who are the X factors, and which storylines ...

Brandon Aiyuk caught four passes for 43 yards in the San Francisco 49ers' Week 2 loss to the Minnesota Vikings. While it may ...

San Francisco 49ers defensive coordinator Nick Sorensen, offensive line/run game coordinator Chris Foerster, and quarterback ...

The San Francisco 49ers suddenly have a host of injury problems, and it's reflected on their second practice report of ...

The San Francisco 49ers are preparing for their Week 3 contest against the Los Angeles Rams on Sunday at SoFi Stadium in ...

The San Francisco 49ers will be without a couple of key players Sunday, but their troubles pale in comparison with the ...

George Kittle and Charvarius Ward not practicing Thursday could mean the San Francisco 49ers will be missing four All-Pros ...

The 49ers added tight end George Kittle (hamstring), cornerback Charvarius Ward (hamstring/knee) and edge rusher Nick Bosa ...

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been ...

The San Francisco 49ers are preparing for their Week 2 contest against the Minnesota Vikings on Sunday at U.S. Bank Stadium in Minneapolis, Minnesota. All eyes are on Christian McCaffrey this week.

San Francisco 49ers safety Talanoa Hufanga is poised to make his season debut on Sunday against the Los Angeles Rams.