eLife20h
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...
eLife3d
Female Moths Incorporate Plant Acoustic Emissions into Their Oviposition Decision-Making Process
This study reveals that female moths utilize ultrasonic sounds emitted by dehydrated plants to inform their oviposition decisions, highlighting sound as a potential sensory cue for optimal host plant ...
eLife3d
Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty
This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...
eLife3d
Axonal injury signaling is restrained by a spared synaptic branch
This important study leverages the power of Drosophila genetics and sparsely-labeled neurons to propose a new model for neuronal injury signaling. The authors present convincing evidence to support ...
eLife3d
Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle
This manuscript provides valuable information about the genesis of CPSF6 condensates due to HIV-1 infection. However, the evidence is incomplete as it is missing more functional assays. Furthermore, ...
eLife3d
Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist
Previous studies in mammals and other vertebrates have shown that a noninvasive measure of cochlear tuning, based on the latency derived from stimulus-frequency otoacoustic emissions, provides a ...
eLife7d
Unique longitudinal contributions of sulcal interruptions to reading acquisition in children
This valuable study relating brain anatomy to reading ability in children studied longitudinally finds that a difference in sulcal anatomy is more predictive of reading ability than cognitive measures ...
eLife6d
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
eLife7d
Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity
Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur ...
eLife7d
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
This important study describes two findings: first, that TEAD is subject to turnover by the ubiquitin-proteasome system involving RNF146 and Parylation, and second, the development of a pan-TEAD ...
eLife7d
Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism
This valuable study explores the role of spatial genome organization in oncogenic transformation, addressing an ambitious and significant topic. The authors have assembled comprehensive datasets from ...