The San Francisco 49ers will travel to Los Angeles in Week 3 to face the Rams at SoFi Stadium. The matchup is set to kick off at 1:25 p.m. PT on Sunday, September 22. Here are all the ways to follow ...

As the San Francisco 49ers continue to grapple with injuries, they travel to Los Angeles to take on the Rams in a tricky NFC ...

The "GMFB" hosts preview what to expect in the Week 3 matchup between the San Francisco 49ers and Los Angeles Rams.

Becoming a star in the NFL is a curse and a blessing. Let's get into our list of the 10 NFL stars with the most heartbreaking ...

Purdy still hasn't entirely shaken the "system" quarterback label and other denigrations. A chance for his rebuttal is now ...

The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but ...

The 49ers are without Christian McCaffrey, Deebo Samuel and maybe George Kittle, while the Rams won’t have top receivers Cooper Kupp and Puka Nacua.

The Rams arrive for this game missing one of the top young ... which could keep him out for several weeks as well. Expect San ...

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed ...

Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

Bruce Marshall is a handicapper for CBS Sportsline. He provides the Review-Journal with NFL betting notes and trends.