A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
FHL-101 is under clinical development by Forest Hills Partners Hong Kong and currently in Phase I for Unspecified Neurologic Disorders.
Etiologies vary by age with metabolic and infectious diseases ... in children than adults but are dependent upon the degree of encephalopathy and diagnosis.
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If the metabolic defect is known in advance ... Over the ensuing few days, signs of a rapidly progressive encephalopathy appeared, with alternating muscle tone (hypo-/hypertonia), dystonic ...
Background: Wernicke-Korsakoff encephalopathy is a metabolic disease caused by vitamin B1 deficiency that predominantly affects alcoholic patients. Its clinical picture is characterized mainly by ...
Some of these contributors are similar to those involved in hepatic encephalopathy, such as systemic inflammation, gut dysbiosis, and metabolic liver dysfunction, which could lead to similar results ...
Inherited metabolic diseases (IMDs) pose a particular challenge ... Specific clinical scenarios are considered below. The investigation of encephalopathy of unknown cause includes tests for IMDs.11 ...
These shifts correlate with functional alterations, including disrupted metabolic pathways and increased ammonia production, ...
Advances in science and technology have allowed researchers to gain a better understanding of the pathophysiology leading to long-term neurologic damage in newborns. Intrapartum events are now ...