Like a lock and key, ketamine binds to the brain via N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are all over the brain and are essential in maintaining consciousness. The study came ...

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...

Ketamine reduces certain nervous system functions by inhibiting normal N-methyl-D-aspartate (NMDA) receptor activity. Normally, NMDA receptors, which are located on the surface of nerve cells ...

Cichon and his colleagues hypothesized that ketamine deactivated certain neurons by blocking their N-methyl-D-aspartate (NMDA) receptor, which is something the drug was already known to do. To probe ...

Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

The clinical-stage biopharmaceutical firm is pushing its NMDA platform while building a national network of psychiatric ...

7 426–437; 2008). Increased levels of glutamate have been found in the frontal cortex of patients with MDD, and the non-selective NMDA receptor antagonist ketamine has shown antidepressant ...

One main class of these drugs, which includes propofol and the ether-derivative sevoflurane, work primarily by increasing the activity of inhibitory GABAA receptors, while a second class that includes ...

Researchers are unsure exactly why ketamine appears to reduce symptoms of depression and anxiety, but they believe the drug goes to the NMDA receptors in the brain, which can help neurons better ...