WASHINGTON — House Republicans are ready to vote on President Donald Trump’s $4.5 trillion tax breaks and spending cuts bill early Thursday, up all night as GOP leaders and the president himself worked to persuade skeptical holdouts to drop their opposition by his Fourth of July deadline.

House Republicans muscled the “big, beautiful bill” through a procedural hurdle on the floor on Wednesday night, setting the legislation up for a final vote.

Brian Fitzpatrick, a Pennsylvania Republican who is one of the most moderate in his party, was a surprising 'no' vote against advancing the bill. Unlike other Republicans who have voted 'no' and are now being courted in person by House Republican leaders, Fitzpatrick raced off the floor and away from the chamber after he voted no.