Acquired DNA mutations found in the SERPINA1 gene can protect liver cells from damage in patients with alpha-1 antitrypsin ...

They also show that models learned from nonsynonymous mutations and from out-of-frame sequences are different, prompting new questions about germinal center function. Strengths of the study include an ...

Somatic mutations in human JAK2 lead to constitutive ... "To understand the molecular and structural basis of the physiological and pathogenic activation of JAK2, we used single-molecule ...

A study of 666 localised prostate tumours identified 223 driver regions, many influenced by structural variations ...

Analysis of structural variations ... discriminate 24 common tumour types based solely on their patterns of somatic mutation, potentially allowing us to determine the identity of tumours of ...