Acquired DNA mutations found in the SERPINA1 gene can protect liver cells from damage in patients with alpha-1 antitrypsin ...

Somatic mutations take place in non-reproductive cells. Many kinds of somatic mutations have no obvious effect on an organism, because genetically normal body cells are able to compensate for the ...

Neurons collected from brain lesions in MS patients were found to accumulate new genetic mutations faster than healthy nerve ...

The way in which blood stem cells evolve over a lifespan differs greatly between humans and mice, new research reveals. The ...

Researchers make hiPSCs by harvesting somatic cells—often from skin—from a person and then reprogramming them to enter an embryonic-like state. Nik-Zainal says that she and her colleagues were clued ...

Some related terminology is “germline” versus “somatic” mutation. A mutation in the germline affects the genes in the cells ...

The way in which blood stem cells evolve over a lifespan differs greatly between humans and mice, new research reveals. The ...

“It’s the first report of somatic mutations being passed [via reproductive cells] in an animal, as far as I can tell,” says Daniel Schoen, an evolutionary biologist at McGill University who was not ...

The research shows that germline and somatic variability work together to initiate ... While both types start from the same ...

as well as cell lineage (i.e. somatic mtDNA and nuclear mutations). In addition to resolving the functional heterogeneity of immune cells throughout the body, we hope to help translate our basic ...