Spatial transcriptomics on human brains parsed microglial reactions to amyloid immunotherapy. Both a vaccine and a therapeutic antibody summoned these cells to plaques. Responders expressed TREM2, ...

For decades, scientists have focused on amyloid plaques—abnormal clumps of misfolded proteins that accumulate between neurons ...

Researchers have developed a stable form of carnosic acid, a compound found in rosemary and sage, for treating Alzheimer's ...

In mouse models, they found that the CSF Aβ42/40 ratio corresponded ... This corresponded with a rise in the Aβ42/40 ratio in both amyloid plaques and protofibrils in the brain (image above).

A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer’s disease is underway ...

For more than three decades, scientists have been racing to stop Alzheimer's disease by removing amyloid beta plaques—sticky ...