The mice used in this study lacked amyloid plaques on blood vessels, so the researchers could not evaluate what happens when blood vessel plaques are removed. They are working with a different mouse ...

Clumps or plaques of the protein beta-amyloid in the brain are a hallmark of a type of dementia called Alzheimer’s disease. When beta-amyloid plaques form, they disrupt communication between ...

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease. Melanie Meyer-Luehmann 1, Tara L. Spires-Jones 1, Claudia Prada 1, Monica Garcia-Alloza 1, ...

Another limitation is that their mouse models only reflect one hallmark of Alzheimer's disease, amyloid beta plaques, not the other hallmark, the neurofibrillary tangles of tau protein within cells.

Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer’s disease that exhibit neurodegeneration. Biomedical Spectroscopy and Imaging , 2013 ...

“We find that in Alzheimer’s disease and its mouse models, induced expression of Axl and Mer in amyloid plaque–associated microglia was coupled to induced plaque decoration by the TAM ligand ...

The amyloid-cascade-hypothesis postulates, based on strong genetic evidences, that Aβ accumulation is the central event in the etiology of AD. Here we use long-term in vivo two-photon imaging to ...

IRA FLATOW, HOST: This is SCIENCE FRIDAY. I'm Ira Flatow. Every good story has a villain, right, and in this case, in the case of Alzheimer's, one of the most notorious villains is amyloid plaque.

Whole blood exchange reduces the formation of amyloid beta plaques in mouse models of Alzheimer's disease. The corresponding study was published in Nature. A buildup of amyloid proteins in the brain ...

Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The ...

Metals such as iron, copper, and zinc are important for many biological processes. In recent years, studies have shown that these nutritionally-essential metals are elevated in human Alzheimer's ...