NFL picks, predictions, odds for Week 5
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Colin Cowherd unveils his Week 5 Blazin' 5, including the Indianapolis Colts (-7) defeating the Raiders and the New York Jets (+3) and Denver Broncos (+3.5) pulling off Week 5 upset wins.
With a two-game lead in the AFC East, the AI PickBot is expecting a knockout punch by the Bills and rates their cover as an A+ pick and also predicts a 34-19 win on average. See its other Week 5 football predictions and football picks at SportsLine.
Bleacher Report's experts waved goodbye to a mediocre September and welcomed a new month with high aspirations.
NFL news is nonstop, and we're breaking it all down week by week this season. Here's the latest on what's happening around the league entering Week 5: Las Vegas Raiders tight end Brock Bowers has been playing through an injury since Week 1.
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NFL Week 5 bold predictions: Drake Maye's Patriots hand Josh Allen's Bills first loss of 2025
The month of October and Week 5 of the 2025 NFL season have arrived, and the San Francisco 49ers treated the football world to a stunning 26-23 overtime road win over the Los Angeles Rams despite a depleted depth chart.
Best Week 5 fantasy football matchups position by position. It's a bye week what quarterback has the best matchup and who are you going to avoid?
On the other side of the ball, the Broncos have a strong run game behind one of the best offensive lines in the NFL, and a second year quarterback in Bo Nix who isn't afraid to let it rip. They're also a lot healthier than the Eagles .
As bye weeks start and the International Series shifts to London, the game of the week might actually be in Jacksonville.
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